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September 27, 2017, Vol. 17, No. 192 |
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Published
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Published ||
Wednesday Edition, September
27, 2017 || Vol. 17, No. 192
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Antibody protects against both Zika and
dengue, mouse study shows |
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By the Washington
University School of Medicine
in St. Louis press staff Brazil and other areas hardest hit by the Zika virus, which can cause babies to be born with abnormally small heads, are also home to dengue virus, which is spread by the same mosquito species. A new study led by researchers at Washington University School of Medicine in St. Louis shows that an antibody that protects against dengue virus is also effective against Zika in mice. Antibodies remain in the bloodstream for weeks, so one or a few doses of an antibody-based drug given over the course of a woman’s pregnancy potentially could protect her fetus from Zika, with the added benefit of protecting her from both Zika and dengue disease, the researchers said. Dengue causes high fever, severe headaches, and joint and muscle pain in children and adults but does not directly harm fetuses. “We found that this antibody not only neutralizes the dengue virus but, in mice, protects both adults and fetuses from Zika disease,” said Michael Diamond, professor of medicine and the study’s senior author. The study was published Sept. 25 in “Nature Immunology.” Since dengue and Zika are related viruses, the researchers reasoned that an antibody that prevents dengue disease may do the same for Zika. Diamond and graduate student Estefania Fernandez collaborated with Gavin Screaton, of Imperial College London, who had generated a panel of human anti-dengue antibodies years before. The scientists infected non-pregnant adult mice with Zika virus and then administered one of the anti-dengue antibodies one, three or five days after infection. For comparison, another group of mice was infected with Zika virus and then given a placebo. Within three weeks of infection, more than 80 percent of the untreated mice had died, whereas all of the mice that received the anti-dengue antibody within three days of infection were still alive, and 40 percent of those that received the antibody five days after infection survived. To find out whether the antibody also could protect fetuses from infection, the researchers infected female mice on the sixth day of their pregnancies with Zika virus and then administered a dose of antibody or a placebo one or three days later. On the 13th day of gestation, the amount of Zika’s genetic material was 600,000 times lower in the placentas and 4,900 times lower in the fetal heads from the pregnant mice that were treated one day after infection, compared with mice that received the placebo. However, administering the antibody three days after infection was less effective: It reduced the amount of viral genetic material in the fetal heads nineteenfold and in the placentas twenty-threefold. |
Washington
University School of Medicine
photo
Antibody
administered
soon after infection with Zika protected the fetuses
of pregnant mice (left), while the fetuses without the antibody
withered away (right).
These findings
suggest that for the antibody to effectively
protect fetuses from Zika infection, it must
be administered soon after infection. Such a
goal may be unrealistic clinically because
women rarely know when they get infected.
However, giving women the antibody as soon as they know they are pregnant could provide them with a ready-made defense against the virus should they encounter it. Antibody-based drugs have been used for decades to provide temporary protection against infectious diseases such as rabies when there is no time to vaccinate or, as in the case of Zika, when there is no vaccine available. The key to using this antibody as a preventive drug would be to make sure that antibody levels in a woman’s bloodstream stay high enough to protect her fetus for the duration of her pregnancy. Diamond and colleagues are working on identifying how much antibody a pregnant woman would need to ensure that her fetus is protected from Zika. They also are exploring ways to extend the antibody’s half-life in the blood, to reduce the number of times it would need to be administered. Having anti-dengue antibodies circulating in the bloodstream for months on end poses a risk, though, because antibodies that protect against one strain of dengue virus sometimes worsen symptoms if a person is infected by another dengue strain. To avoid the possibility of accidentally aggravating an already very painful disease, the researchers mutated the antibody in four spots, making it impossible for the antibody to exacerbate dengue disease. “We mutated the antibody so that it could not cause antibody enhancement of dengue infection, and it was still protective,” said Diamond, who is also a professor of pathology and immunology, and of molecular microbiology. “So now we have a version of the antibody that would be therapeutic against both viruses and safe for use in a dengue-endemic area, because it is unable to worsen disease.” |
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medical care
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A.M. Costa Rica Fifth news page |
Published
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September 27, 2017 || Vol. 17, No. 192
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Want to read more? Check out
these books listed below! |
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Costa Rica: Remarkable
Tales from Our Super Vacation Spot
By the staff and contributors at A.M. Costa Rica & James J. Brodell (editor)A.M. Costa Rica celebrates its 16th anniversary with a compilation of classic news reports geared to the needs of foreigners living here and those elsewhere with personal or business interests in this vacation paradise. Each seeks to tell something new or original about the vacation and retirement mecca. Read a sample and purchase the book HERE! |
Trapped In The
Damas Cave, Costa Rica
A true story by author Dusty
Pilot, who lived in Costa Rica for 11 years. Dusty tells
his horrifying story of being trapped in the Damas Cave,
near Quepos, for 26 hours. The book is available from
Amazon in both digital and print format. Digital format
will be on sale for $0.99 until Aug. 30. Visit Amazon.com
to preview or purchase, or DustyPilot.com/cave.html More information Contact Dusty
Pilot Email: dusty@dustypilot.com US
phone: 001 440 796-4105¯
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The Trouble with Cash
By John H Paterson Greg and Liz must sell their property in Costa Rica to finance their retirement. They receive an offer for their full asking price of $1 million, but it comes with one condition...the payment is to be in cash. They go for it. Things go wrong. The money is stolen.The local police are no help so Greg devises his own plan to get their money back. Review or buy the book on Amazon ON SALE FOR $0.99 Click Here Email: j.paterson@riomagnolia.com Phone: (506) 8868-5561 Watch book trailer here: |
New World Meditation:
Focusing-Mindfulness-Healing-Awakening
By Lucinda Gray PhD You will be Free to Live, Love, Work and Play in the Full Creative Expression of Your Authentic Self. New World Meditation is easy to learn, easy to practice, and profoundly transformational. More information HERE! |
MAKE GIFTS FROM DOLLARS OR
COLONES
Running out of gift ideas? Author Dusty Pilot has just released easy to follow, step-by-step instructions for turning bills (dollars or colones) of any denomination into unique gifts such as flowers: roses, daffodils, daisies and poinsettias; shirts and blouses, and birds with flapping wings. The book is being discounted to $0.99 through October 31. It is available at all major online book stores. Preview or purchase at Amazon or visit DustyPilot click here. Buy this book at Smashwords For more information Contact Dusty Pilot: Email dusty@dustypilot.com. Phone 001 440 796-4105 |
Life is a Tropical Garden By Victoria
Torley
A quirky look at gardening in the tropics. What happens when a "Northern" gardener moves to Costa Rica? You have no idea…. Email: victoriatorley1@gmail.com. Order this book here: https://www.amazon.com/dp/1522005986/ref=rdr_ext_tmb |
The Dark Side of Pura Vida: Murder,
Betrayal, Abduction and Revenge in the Vacation
Paradise
By James J. Brodell. Retired baseball player Jack Patterson becomes suspicious after his younger sister dies in a Pacific Ocean rip tide while on vacation in Costa Rica. Jack has to go there to find answers to troubling questions. But soon he is hijacked by a gang of avengers led by an icy Costa Rican-American woman who carries twin pistols strapped to her chest. Jack soon helps uncover a web of corruption and greed . Read a sample and purchase the book HERE! |
Guide to Costa Rican
Spanish
(English and Spanish Edition) This one-of-a-kind
best-selling Costa Rica Spanish phrasebook will
help anyone including older retirees master the basics of
using Costa Rican Spanish in real-life situations.
Retirees, expats and tourists will get the most of of
Costa Rica, be able to communicate effectively with Costa
Ricans and understand the local culture. A practical
pronunciation will help you sound a like a native Spanish
speaker. The book is now available for sale on
Amazon click here
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What we published this week: | Monday | Tuesday | Wednesday | Thursday | Friday | Earlier |
The contents of this Web site are
copyrighted by Consultantes Río Colorado S.A. 2017
and may not be reproduced anywhere without
permission. Abstracts and fair use are permitted. Check HERE for details |
From
page 6: Costa Rican groups chosen for German event By the A.M. Costa Rica staff At least 40 companies from the information and communication technologies sectors were selected to participate in the second edition of the Programa de Gerentes, an initiative of the German Federal Ministry for Economic Cooperation and Development. According to a statement from Costa Rica’s Promotora de Comercio Exterior, the program seeks to increase competitiveness of Central American small businesses by a so-called internationalization of their businesses with Germany. “We are very happy with the results of this second competition,” said Irina Kausch, director of the German initiative in Central America. “The proposals come from very strong companies in each sector. We hope that after the training process, 20 of these companies with the greatest potential will travel to Germany.” According to the initiative, over 47 proposals were received from the five participating countries. The selection was carried out by the German counterparts in each country. In Costa Rica, that is PROCOMER. “We are very pleased that this group of 11 Costa Rican companies are part of this GIZ Program project,” said Álvaro Piedra, the director of exports at PROCOMER. “This initiative will allow them to share good practices, learn trends and learn new methods, which will help them to be more competitive to reach markets as demanding as the German ones.” Once selected, companies will participate in a coaching and training process to strengthen their marketing skills, their knowledge of the German economy and the possibilities of creating business partnerships with German allies, PROCOMER said. At the end of this process, a new evaluation will be made of the business proposals presented by the companies. The companies with the greatest potential will be selected for a business trip to Germany to network and participate in trade fairs and business meetings. |